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The mutation of GLP-1 positions 16, 17, 18, and 20 into Ala showed minor effects (IC 50 from 0.27 nM to 1.7, 0.46, 0.68, and 1.7 nM

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However, a small sample found that Lira did not significantly change levels of the hepatic fat oxidation marker -hydroxybutyrate, although it reduced liver fat [68]

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