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Michaowicz J, Wuka A, Bukowska B

Keeping an eye on how its going and making changes is key to success

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These processes play key roles to promote chemoresistance in tumors, where elevated GSH inactivates electrophilic chemotherapeutic agents (cisplatin, alkylators), GSTs enable drug conjugation, and MRP-catalyzed efflux reduces intracellular drug levels - while inhibiting therapy-induced oxidative stress at the same time

10.1093/TOXSCI/KFP274 89 JuknatA.KozelaE.KaushanskyN.MechoulamR.VogelZ

Use of pharmaceutical grade and non-pharmaceutical grade substances in vertebrate animals (IACUC)