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Design and evaluation of bi-functional iron chelators for protection of dopaminergic neurons from toxicants

In summary, ROS contribute to various aspects of necroptosis, including the initiation of signaling cascades, amplification of key protein activity, modulation of energy metabolism, activation of MLKL, and the establishment of a feedback loop

[3][7][10] These treatments should only be prescribed as a second-line treatment for weight loss, following attempts to lose weight with diet and exercise

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10.1136/bmjpo-2022-001460 230

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