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DAMPs also impact Kupffer cells, activating the nucleotide-binding oligomerization domain-like receptor (NLR) Family, Pyrin Domain-Containing 3 protein (NLRP3), a type of inflammasome leading to IL-1 secretion and inflammation, and pyroptosis, releasing more DAMPs and perpetuating a destructive cycle (Peiseler et al., 2022)
A later experimental study assessed endocrine responses in healthy volunteers, while other preclinical work investigated ghrelin-receptor-related gastrointestinal signalling in rodents
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If approved, retatrutide might be the most effective weight loss medication available in Canada
Additional metabolic effects include fatty acid oxidation, gluconeogenesis, and energy expenditure