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This loss of muscle can lead to an increase in body fat percentage, particularly around the abdomen

Summary of included pre-clinical and mechanistic studies regarding the effects of GLP-1-RAs on mental health outcomes)

20 AT 1a receptors are also expressed in the liver, adrenal gland, ovary, heart, aorta, lung, testis, brain, adipose tissue and vascular smooth muscle, whereas AT 1b receptors are confined to the adrenal gland, brain and testis

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Short-chain fatty acids stimulate glucagon-like peptide-1 secretion via the G-protein-coupled receptor FFAR2