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Yes - Valid for Submission Chronic Condition Indicator: [1] Not chronic Code Navigator: R73.9 is a billable diagnosis code used to specify a medical diagnosis of hyperglycemia, unspecified

Compared to males, females had approximately 25% higher exposure values for the active metabolite than males, but this difference is unlikely to be of clinical relevance

Interestingly, despite the lack of metabolic consequence in hepatocyte RAMP2-overexpressing mice, hepatocyte-specific knockdown of the endosomal protein VPS37a within in vitro and ex vivo settings increases ligand-bound GcgR localization into G s accessible endosomes, enhances total G s /cAMP signaling, reduces lysosomal targeting, and alters endosomal localization which when applied in vivo significantly upregulates glucose production and biases hepatic metabolic flux away from fatty acid oxidation [164]

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Employed in in vitro research examining cooperative GHRHR and GHSR-1a co-stimulation in dual-receptor cell line models and cAMP accumulation assays