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Statements Author contributions HX: Writing original draft, Software, Investigation, Formal analysis, Writing review & editing, Supervision, Conceptualization

In a similar way as other insulin containing products, the dose should be titrated once a week according to the individual patients glycemic target range [37]

Following the therapy was a consistent counteraction of early and full multiorgan failure (and heart failure, in particular) and thrombosis of the described occlusion/occlusion-like syndrome [66,71,72,73,74,75,76,77,78,79,80,81,82], peripherally and centrally, and thereby, counteraction of the later isoprenaline-infarction and isoprenaline-reinfarction [79]