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[1] Martello E et al
The low pH of these acids destabilizes the copper peptide complex, potentially reducing its effectiveness and increasing irritation risk
Front Aging Neurosci 12:625166
An exciting experimental platform to explore this possibility is activity-based profiling
Abbreviations Pb lead ROS reactive oxygen species GSH glutathione MDA malondialdehyde Nrf2 nuclear factor erythroid 2-related factor 2 HO-1 heme oxygenase 1 ARE anti-oxidative response element SOD superoxide dismutase ER endoplasmic reticulum UPR unfolded protein response GRP78 glucose-regulated protein 78 PERK protein kinase RNA-like ER kinase CHOP C/EBP-homologous protein
Conclusion In summary, we successfully incorporated two cell-targeting motifs into tripeptide-1 (GHK), a well-known cosmetic peptide, resulting in the development of two chimeric peptides, namely, RGD-GHK and sOtx2-GHK
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