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Scripps Clinic obesity and internal medicine specialist Mitch Biermann, MD, PhD, and Scripps Clinic internal medicine resident Michelle Wong, MD, report in the medical journal Obesity that most participants in their small clinical study sustained their peak weight loss from the popular medications even after reducing the dose frequency to once every two weeks and, for some patients, as infrequently as once every six weeks
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The anti-inflammatory effect of GLP-1RAs may be mediated through the inhibition of p38 MAPK/NF-B pathway activation, as activated p38 MAPK/NF-B promotes the gene expression of TNF-, IL-6 and IL-1 (147)
10.2337/dc15-0811 [DOI] [PubMed] [Google Scholar] 82.Bianchi C, Daniele G, Dardano A, Miccoli R, Del Prato S
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