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Unfortunately, our food quality isnt what it used to be or we have genetic markers that make it harder for us to absorb nutrients

The compaction of protein at low pH occurs due to the deionization of polar amino acid residues present in the interior of the protein that leads to a decrease in electrostatic repulsions

doi: 10.1093/cvr/cvab263 104 Roll-MecakA

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GoF receptors are often characterised by a greater propensity for G protein versus -arrestin recruitment and signalling, slower rate of receptor internalisation and rapid recycling back to the plasma membrane, with these characteristics being independent of their surface expression levels (Liu et al., 2022)

Appetite suppression begins immediately, but meaningful weight loss typically starts within 4 weeks