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Mechanism of Action Sermorelin acts as a selective agonist at the pituitary GHRH receptor (GHRHR), a G-protein-coupled receptor expressed on somatotroph cells

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In direct comparison studies using rat pituitary cell cultures, Ipamorelin produced dose-dependent GH release with an EC50 similar to GHRP-6 but showed no measurable ACTH or cortisol increase even at supraphysiological concentrations up to 200-fold above its GH-releasing EC50

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Do not skip doses Semaglutide builds up in your system over time to maintain consistent GLP-1 receptor activation