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What you should hear in this paragraph: mechanism plus extrapolation is a starting point for hypothesis, not a substitute for population-specific trial evidence

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doi: 10.1001/jama.292.23.2901

In fact, the findings from recent studies suggest that prolonged treatment with NAC may be detrimental for recovery after APAP overdose.16, 17 Unfortunately, in patients who do not respond well to NAC therapy, liver transplantation is the only other option

Expression levels of insulin, TGF-1, -SMA, and collagen I were normalized to that of -actin and expressed relative to that in the sham group [22]

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