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The NHS advises reducing your calorie intake by 600 calories every day, which is known as a calorie deficit

Refrigerated reconstituted SLU-PP-332 should be used within 28 days, and any temperature excursion above 8C for more than 4 hours likely triggers irreversible potency loss

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For patients without absorption disorders, high-dose oral supplements of 1,000 to 2,000 mcg daily have been shown to be comparably effective at correcting mild to moderate deficiency at lower cost and greater convenience.

Standard dosing ranges from 2-5mg administered subcutaneously two to three times weekly

Imaging studies (X-ray, MRI, ultrasound) documenting initial status for comparison