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Results: The core mechanism of MR lies in disrupting one-carbon metabolism and epigenetic regulation that rely on methionine, depleting the crucial metabolite S-adenosylmethionine (SAM), thereby inhibiting histone/DNA methylation, disrupting redox homeostasis, and ultimately inducing cell cycle arrest and apoptosis

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Auspiciously, we found that PKM2 mediates DRD2-induced GSH production and is selectively expressed in astrocytes, indicating that PKM2 dimerization is an ideal approach to restore GSH synthesis and prevent side effects induced by effects on neuron functions