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The brain, despite accounting for only 2% of total body weight, consumes about 20% of the glucose we ingest

Li Y, Liu B, Li Y, Jing X, Deng S, Yan Y, et al

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Beyond these clinically recognized effects, sustained caloric restriction during pharmacological weight reduction represents a chronic constraint on systemic energy flux

In addition GLP1 receptor agonism also potently protects against acute olanzapine induced perturbations in carbohydrate and fat metabolism which correspond with reductions in the glucagon:insulin ratio (Medak et al., 2020)

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