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Clinical trial data from SUSTAIN-6 (2016) and subsequent studies show semaglutide users achieve significant reductions in fasting glucose, triglycerides, and C-reactive proteina marker of systemic inflammation

The CDC's diabetes research hub provides helpful context on how insulin dysregulation intersects with obesity and body composition, underscoring why this pathway must often be addressed before meaningful fat loss can occur

The wide-ranging effects are believed to stem from the broad expression of glucagon-like peptide-1 receptors in extrapancreatic tissues

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This allows the medication to clear out of your system, which prevents overlapping side effects

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