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Wiesmann T, Castori M, Malfait F, Wulf H

Lifestyle interventions (including diet, exercise and behavioural changes) are the cornerstone of obesity management with diverse benefits, but even the most intensive lifestyle interventions result in up to 10% mean weight loss (WL) and weight maintenance remains a challenge, as 80% of WL is expected to be regained over the next 5 years [4, 5]

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The clinical result: patients on apixaban 5 mg twice daily experience major bleeding at a rate of 2.13% per year, compared to 3.09% per year on warfarin, based on ARISTOTLE data [3]

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