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At the intestinal level, TMAO can downregulate tight junction proteins, such as Claudin-1, alter the Firmicutes/Bacteroidetes ( F/B ) ratio, reduce the microbiotas resilience to stress, and promote the elevation of harmful metabolites, thereby inducing systemic inflammation (Chen et al., 2022)

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Abstract Paraxanthine (PXN) is the main metabolite of caffeine (CAF)

Its unique Ec domain provides a mechanistically distinct signal from systemic IGF-1 analogues, allowing researchers to study the local muscle precursor cell response independently of systemic anabolic signalling

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