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Historically, for many OECD in vitro Test Guidelines (TGs), the initial focus has been on (dichotomous) hazard identification particularly for classification and labelling needs, but also based upon the extent to which the results from the validation study can be reliably interpreted

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Glutathione, glutathione peroxidase, and superoxide dismutase were decreased in liver biopsies from NAFLD patients and in mitochondria from animal models of NAFLD [82, 87], closing the loop on a vicious cycle in which the diminishing capacity of the antioxidant defense system is continuously being depleted by rising ROS levels

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JCI Insight (2024)