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The article defines pharmacogenomics as the field investigating how a person's genetic makeup influences drug response

In contrast, LepR is expressed in sub-populations of neurons located in the lateral hypothalamus (136138) a region known to directly and indirectly influence the histaminergic neurons (139, 140)

suggests that TB-500 may interact with cell movement as it binds globular actin (G-actin) and may modulate how actin filaments assemble to plausibly make endothelial cells more able to change shape, migrate, and form multicellular structures

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