Tirzepatide is an approved, extensively studied dual agonist with a proven safety record, commercial availability, and the most comprehensive Phase 3 dataset in the GLP-1 class
In patients with BMI over 30, exenatide produced a statistically significant reduction in heavy drinking days compared to placebo
For patients where synovial fluid analysis is unfeasible, imaging techniques such as ultrasound and dual-energy computed tomography (DECT) can detect urate deposition, with sensitivities ranging from 15% to 40%
It may be that the main impact of physiologic insulin regimens and insulin glargine, in particular, is that the separation of prandial and basal components improves our understanding of insulin use, simplifies dosing adjustments, and allows patients more flexibility in meal timing
Antonetti DA, Klein R, Gardner TW
For instance, they can enhance growth factors, stimulate collagen production, or optimize immune function, ensuring the body operates at its peak potential