Healthcare providers should conduct a thorough evaluation of patients reporting muscle cramps on GLP-1 therapy
For example, GLP-1R/GIPR dual agonists have demonstrated superior glucose-lowering and weight-loss effects in the treatment of diabetes and obesity
They increase insulin response, lower blood glucose, suppress appetite, and lead to weight loss
They can assess your symptoms, review your treatment plan, and suggest adjustments or additional interventions to help manage your fatigue
This integrated view can support a richer provider discussion about candidacy, expected response patterns, and whether compounded semaglutide or alternative peptide options may be most aligned with your health profile and goals
However, it wont be effective if one medication is not working for you, and you need something more effective for better blood sugar control