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Extended-release metformin formulations were subsequently approved (50), and the first extended-release liquid formulation followed more recently (51, 52)

Administration : Subcutaneous or intramuscular injection, sometimes near the injury site

Many traditional forms are broken down in the digestive tract before they can be absorbed

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Notably, MSCs engineered to overexpress let-7a have been shown to alleviate PAH progression by inhibiting PASMC growth through the STAT3-BMPR2 signaling cascade, thereby supporting a promising therapeutic strategy for PAH patients (Cheng et al., 2017b)

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