NICE guidance recommends GLP-1-based therapies for adults with type 2 diabetes who have inadequate control despite treatment with metformin and other oral agents, with individualised targets based on your specific circumstances
Preclinical and translational studies indicate that multi-receptor agonism can influence liver fat measurements, hepatic triglyceride handling, cholesterol metabolism, and biochemical markers associated with liver function
However, 2024 clinical practice guidelineswhich were endorsed by the American Society of Anesthesiologists and several other professional medical societiesexplain that this blanket recommendation is not necessary
Exercise helps maintain weight loss without relying on medication
The larger your target, the more meaningful the incremental advantage of tirzepatide or retatrutide becomes
Triglycerides: High triglycerides indicate excess VLDL particles that deposit fat in arterial walls