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This disease was first described in 1971 by Nagashima, a Japanese dermatologist (234, 235)

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In the Retatrutide diabetes trial, gastrointestinal adverse events appeared in roughly 35 percent of treated participants, the same family of effects seen across this drug class, and no severe low-blood-sugar episodes or deaths were reported

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For a 75 to 90kg adult, that translates roughly to 190 to 900mcg daily, which brackets the 200 to 500mcg range being used in practice