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Modulation of the permeability transition pore Studies have reported that mitochondria permeabilize due to the mitochondrial permeability transition pore (mPTP) opening, a pathophysiological event that, under favorable conditions, causes an increase in permeability of the inner mitochondrial membrane and leads to mitochondrial depolarization, swelling, and the activation of the apoptotic and necrotic pathways 43

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At the submandibular margin with a pinch thickness of only 18 mm, using a 13 mm for a 90-degree injection will cause the tip to touch and penetrate the platysma fascia at the bottom of the fat layer

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