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Whereas the monomers and the protofilaments are harmless, the oligomers are cytotoxic and induce cell death in primary neuronal cells, fibroblasts, and neuroblastoma cells [69]

McConnell, M

As estrogen receptors are ubiquitously distributed, they can modulate cell proliferation, differentiation, and survival in several tissues and organs, including the central nervous system (CNS)

Moreover, given that ionomycin induces PS exposure in all conditions, it emerged as an effective positive control to test eryptosis levels in vitro