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Senescence: a double-edged sword in beta-cell health and failure

Among which, glucose-6-phosphate isomerase (GPI), 2,3-bisphosphoglycerate-independent phosphoglycerate mutase (GPMI) and phosphoglycerate kinase (PGK) were three most differentially expressed genes, showing the value of log2 fold-change (log2FC) 3.48, 3.46 and 2.85, respectively, at 3 DPI vs CK (Additional file 1: Dataset S1)

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TB-500 provides neuroprotection through anti-apoptotic effects via caspase-3 inhibition

However, not only does p62 prevent NRF2 binding to KEAP1, it induces autophagic degradation of KEAP1, resulting in a positive feedback loop of NRF2 activation [82]