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During the GLP-1 drug shortages of 2023 and 2024, compounding pharmacies stepped in to fill the gap, offering compounded semaglutide and tirzepatide at lower prices than brand-name versions

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It may also be picking up a real limit: that the sense of feeling better, once weighed against nausea, muscle loss and the burden of a long-term injectable, is smaller and less durable than it looks in the clinic