In some cases, yesespecially if you have a diagnosed deficiency
At 1.67mg/ml, a 0.25mg dose requires about 0.15ml (15 units)
Pro-inflammatory factors such as interleukin-1 (IL-1), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-) are regarded as depression biomarkers ( The Acanthopanax senticosus polysaccharides (APSP) demonstrated a reduction in the levels of pro-inflammatory factors IL-1, IL-6, and TNF-, while simultaneously increasing the expression of p-PI3K, p-Akt, and p-mTOR proteins induced by chronic mild agnostic stress stimuli in rats ( Ganoderma lucidum polysaccharides (GLP) significantly mitigated the downregulation of pro-inflammatory cytokines in BV-2 microglia induced by LPS or a, while promoting the expression of anti-inflammatory cytokines in both BV-2 and primary microglia (Li et al., 2021)
MOTS-c increases cellular NAD+ levels as part of its mechanism, so the two compounds work through complementary pathways rather than redundant ones
Bharadwaj, S., Naidu, T
Acetyltransferase 10 (NAT10) regulates the stability and protein expression of FSP1 via modulation of the mRNA of the N4-acetylcysteine site, which in turn affects the stability and translation efficiency of the mRNA
