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Vitamin B12 is generally very safe even at high doses because it is water-soluble and excess amounts are excreted in urine

Side effects are different, too

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This is achieved, in part, by modulating the expression of pro-angiogenic factors such as Vascular Endothelial Growth Factor (VEGF) and Fibroblast Growth Factor 2 (FGF-2)

Most people take between 500 mcg and 1,000 mcg of OTC vitamin B12 per day