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7 Initiating and monitoring If adding a DPP-4 inhibitor to sulfonylurea, meglitinide or insulin therapy, consider whether a dose reduction of the sulfonylurea/meglitinide/insulin is needed to reduce hypoglycaemia risk

Ipamorelin is a selective ghrelin-receptor (GHS-R1a) agonist

Cagrilintide works differently than specific GLP-1 agonists because it activates amylin receptors, which are heterodimeric complexes of calcitonin receptor with proteins that change the function of receptors

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1 PVN GLP-1R neurons project to different downstream targets