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It is worth noting that the tumors only increased by 2.76 times even using the DOX/LAAM GSH-CQDs at 2 mg kg 1 , which still showed a better treatment effect than the DOX and Doxil groups

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Long-term HFD consumption increased hepatic IKK- glutathionylation and NF-B suppression The mechanistic investigations in our cell culture studies provided evidence suggesting that intracellular GSSG accumulation sensitizes hepatocytes to TNF cytotoxicity via the induction of IKK- glutathionylation, leading to reduced IKK- phosphorylation and subsequent NF-B suppression