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Relative luminescence units (RLU) were recorded in a Flexstation 3 plate reader and results normalised to islet cell counts

However, they were closely linked to many processes associated with inflammation, including cell proliferation (NES, NME1, PRAME), endocytosis (NME1, RAB1A, DNM2, TRIP10), protein folding (VBP1, CRTAP, PDIA5), cell adhesion (RAB1A, DNM2, ICAM1), proteolysis (LONP1, PRSS23) and transcription (TPR, PRPF6, HIST1H1B, HIST1H1E, PRAME, DNME2)

This enzyme is, however, highly expressed in human liver, testes, and kidney (7)

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IGF1 is primarily produced in the liver, but it is also synthesized by almost all tissues, including the testes [13, 14]

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