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By combining rational peptide design, strategic amino-acid substitutions and albumin-binding acylation, with systematic, hypothesis-driven experimentation, investigators achieved a pharmacokinetic profile (approximately 160 h half-life) that made OW dosing clinically feasible without compromising receptor potency or safety

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This dual dependency on CYP3A4 and P-gp creates a well-defined vulnerability

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Like minoxidil, some users report a brief increase in shedding during the transition into new growth phases