This minimizes the time the peptide spends in a highly diluted state, which can sometimes reduce its stability
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After supply disruptions for semaglutide and tirzepatide ended, facilities continued producing glucagon-like peptide-1 receptor agonists (GLP-1 RAs) using compounded formulations that include added ingredients, according to a study published in JAMA Health Forum (doi:10.1001/jamahealthforum.2026.2207)
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In the SURMOUNT-1 trial, participants without diabetes achieved average weight loss of 15-20% of baseline body weight over 72 weeks at the highest doses, with somewhat lower reductions observed in people with type 2 diabetes
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