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While a negative feedback loop has not been identified, the very high levels of these medications not only flood the body, but do so for extended periods, unlike endogenous GLP-1, which normally fluctuates in response to eating

Rapid injection forces medication into tissue faster than it can disperse, creating pressure that feels like a burning sting

At 12mg: Similar GI symptoms to the 8mg transition, though the body has already adapted to much of the receptor activation by this point

This is because GLP-1 medications appetite-suppressing hormonal effects reverse within weeks of stopping

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Reconstitution and injection preparation require a clean surface