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In contrast, in untreated rats, higher activities of microsomal NADPH-cytochrome c reductase, 7-ethoxycoumarin o-deethylase, 7-ethoxyresorufin o-deethylase, and cytosolic glutathione transferase were found in the centrilobular hepatocytes (Bengtsson et al

Moreover, while all the complexes displayed common and extensive interactions between the GLP-1R and the 5 helix of G s , the persistence of interactions with individual residues differed in the exendin-P5 and oxyntomodulin bound complex (and to a lesser extent exendin-4), relative to GLP-1 over the time-course of the simulation (Figure 8B, Supplemental Table 4)

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Inoue, Masaki, Haruhiko Kamada, Yasuhiro Abe, Kazuma Higashisaka, Kazuya Nagano, Yohei Mukai, Yasuo Yoshioka, Yasuo Tsutsumi, and Shin-ichi Tsunoda