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(2) M A Heffernan 1, A W Thorburn, B Fam, R Summers, et al (2001) Increase of fat oxidation and weight loss in obese mice caused by chronic treatment with human growth hormone or a modified C-terminal fragment International Journal of Obesity and Related Metabolic Disorders, 2001 Oct, Volume 25 (Issue 10), Pages 1442-9

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Introducing methyl substituents on carbon atoms adjacent to the disulfide bond increases steric hindrance, enhancing stability in the blood