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Abstract Due to their cardiovascular protective effect, glucagon-like peptide-1 receptor agonists (GLP-1RAs) and sodium-glucose cotransporter-2 inhibitors (SGLT2is) represent breakthrough therapies for type 2 diabetes mellitus (T2DM)

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Penteado LdeA, Dejani NN, Verdan FF, Orlando AB, Nio VE, Dias FDN, et al

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Intriguingly, semaglutide upregulated ITIH3 expression, a mitochondrial respiration enhancer inversely associated with MAFLD severity (28), and downregulated ACAT1, suggesting improved metabolic homeostasis through ketogenesis-lipolysis balance modulation (29)

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