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They transiently peak as the drug is absorbed after each dosing occasion and gradually fall thereafter, reaching a trough just before the next dosing occasion

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In experimental systems, DSIP has been shown to influence second messenger activity and hormonal signaling cascades linked to the hypothalamicpituitaryadrenal axis, including regulation of adrenocorticotropic hormone and related endocrine mediators [4]

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This is usually performed with laparoscopic surgery