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Compounded semaglutide is a customized medication prepared by a licensed pharmacy

Each form oral or injectable leads to significant weight loss, with preference depending on personal comfort and lifestyle needs

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The Step-HFpEF Trialists took 529 patients with proven HFpEF and typical heart failure symptoms (tiredness, breathlessness, limitation of physical activity) and a BMI of greater than 30kg/m2 (obese) and randomised half of them to receive the semaglutide injections and half to receive a placebo (a dummy injection) for 52 weeks