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It is derived from a partial sequence of human gastric juice protein and has been extensively studied in preclinical models for its effects on gut mucosal integrity, wound healing, tendon and ligament repair, and angiogenesis
The half-life of DSIP depends on its environment: In vitro, it exhibits low molecular stability due to the action of specific aminopeptidase enzymes, with a half-life of only 15 minutes
Expression levels of matrix metalloproteinase-2 (MMP-2) and MMP-9 can be utilized as biomarkers to assess the metastatic potential of ovarian cancer and the invasiveness of breast cancer cells [83, 84]
Funding This work has been partially funded by the Spanish Ministry of Health, Instituto de Salud Carlos III (ISCIII), FIS PI14-01962, and the Andalusian Government grant BIO177 (FEDER funds of European Commission)
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