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Top-Down Approach The top-down approach used macro-level indicators: Parent market benchmarks Global/regional industry trends Economic indicators (GDP, demographics, spending patterns) Penetration and usage ratios This approach was used for segments where granular data were limited or inconsistent

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Also, if there is no clinical data for a substance, and an awareness that the substance has the propensity for harm, that could make it an appropriate placement on the Category 2 list. Are They Safe