So, the anti-inflammatory properties of these bioactive compounds help to inhibit the onset of chronic inflammation and thus cancer development (20)
Long-term PPI use carries some considerations, such as reduced vitamin B12 absorption and potential calcium metabolism changes, but many patients tolerate them safely for months while adjusting to semaglutide therapy
However, these agents increase risk of intra-operative pulmonary aspiration according to a case report secondary to delayed emptying and presence of gastric residues despite fasting (108, 108) To prevent these events, the recent recommendations from the American Society of Anesthesiology guidelines suggest discontinuing GLP-1 receptor agonists 1 day prior in patients on daily dosing and 1 week prior in patients on weekly injection dosing (108)
No wonder adherence declinesup to 50% of users drop out because of side effects
Weeks 2-3: metabolic shifts begin This is when the metabolic machinery starts turning
The SURMOUNT-4 trial with tirzepatide showed that participants who continued the medication lost an additional 5.5% of their body weight, while those who switched to a placebo regained 14%
