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Foundayo (Orforglipron) Developed by Eli Lilly, Foundayo is an oral, non-peptide GLP-1 receptor agonist that has generated considerable excitement because it offers weight loss approaching that seen with injectable medications while avoiding injections altogether

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doi: 10.1111/j.1365-3040.2011.02400.x 46 OchiT

Treatment with GLP-1RA significantly attenuated high glucose-induced tubule damage in DKD kidney tissues and TECs cells (177)

Tolerability Issues : The adverse events with the GLP-1-based therapies are primarily gastrointestinal and include nausea, vomiting, constipation, or diarrhea [82], leading to meaningful discontinuation rates that limit real-world effectiveness

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