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Additionally, patients experienced modest weight loss averaging 2 to 3 kg over 6 months, an unexpected but welcome effect that distinguished GLP-1 receptor agonists from many other diabetes medications that cause weight gain

Theyre also expected to cause similar side effects, including low blood sugar and fatigue

Int J Dermatol 58(10):12021204

These experiments implicate macropinocytosis as the mechanism by which GLP-1(2836) enters vascular cells

The learning curve with GLP-1 medications involves understanding injection technique , managing the initial adjustment period where gastrointestinal side effects peak, and following proper injection site rotation

g , Left, Cre-dependent H129-TK-TT was injected into the DVC of Glp1r-ires-Cre mice (n = 3)