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Research has examined GLP-1R expression in hypothalamic nuclei and brainstem areas involved in energy balance

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On further time-based analysis, we demonstrated a modest reduction in weight with GLP-1 RA use within the first 3 years (2.7% of baseline body weight) before rebounding to above baseline at 5 years

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However, many people have started to question, Does Ozempic cause depression? Reports have suggested a potential link between GLP-1 and other weight loss medications and mental health concerns, including depression and other psychological changes