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After ligand binding, the three tyrosines of the a-loop are transphosphorylated by the dimeric subunit partner
These could cause strand breaks in either one or both strands of the nucleic acid, which will render it ineffective
These characteristics make it a frequent focus in recovery-oriented research protocols
Their research revealed complement and coagulation cascade pathways play significant roles in AKI development and progression, and icariin attenuates AKI by suppressing these signaling cascades
Development 135 , 21932202 (2008)
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