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Further, using a combination of genetic and pharmacological tools, our data suggest that islet-derived rather than intestine-derived GLP-1 also contributes to the therapeutic efficacy of DPP-4 inhibitors

What This All Adds Up To If you zoom out, the GLP-1 story is fundamentally about the collision of three forces that rarely intersect at the same moment in pharma history

Although some studies have reported positive outcomes when using AOX therapy in conjunction with other fertility treatments, the evidence remains mixed, and large-scale RCTs are needed to confirm its efficacy and safety

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Am J Physiol Endocrinol Metab 305: E475-484, 2013